Enabling precision medicine with AI-driven interpretation
For all NGS testing from whole genomes and exomes to targeted panels
Fabric Genomics, a GeneDx company, offers the leading AI-based platform for NGS analysis, interpretation, and clinical reporting for rare disease, hereditary risk, and cancer testing with best-in-class accuracy and scalability.Â
Dozens of the worlds leading hospitals, clinical labs, and academic centers such as Cincinnati Children’s, InterMountain, Rady Children’s Institute,  and others count on Fabric AI technology and Fabric’s clinical services for their complete NGS software and services needs.Â
Why Fabric?
Diagnostic Yield
- 98% of causal variants ranked in the top 5 by GEM for rare disease
- ACMG-compliant classification backed by validation across
> 50,000 variants
& Efficiency
- 10 times more cases with the same team
- Average clinical review time of 15min for WGS
- Optimized workflow for efficient throughput, secure, API integration with LIMS & EMR
& Services
- Get up and running in as little as 4 weeks
- Software Set up & Lab Validation
- Panel curation and SOP design
- Interpretation and signout
Leadership
Martin Reese, Ph.D.
Co-Founder, President, and CEO
A recognized leader in genomics and bioinformatics, Dr. Reese has co-founded and helped build three influential companies in the field – Neomorphic, IDbyDNA, and Fabric Genomics.
At Neomorphic, he developed genome annotation software that enabled Affymetrix’s successful commercialization of microarray technology. He went on to launch IDbyDNA, a spinout from ARUP Laboratories, where he led the creation of the first real-time, web-based pathogen interpretation platform; the company was acquired by Illumina in 2022. Dr. Reese has also played a key role in collaborative efforts to advance genome annotation, contributing to the Berkeley Drosophila Genome Project and developing gene-finding algorithms in support of the Human Genome Project. He holds a master’s degree in Medical Informatics from the University of Heidelberg and a Ph.D. in Genetics jointly awarded by the University of Hohenheim, Germany, and the University of California, Berkeley.
His work has been instrumental in advancing genome annotation, machine learning in genomics, and the broader field of precision medicine.
Martin Reese, PhD.
Co-Founder, President, Board Member, and CEO
Martin Reese, Ph.D.
Co-Founder, President, and CEO
A recognized leader in genomics and bioinformatics, Dr. Reese has co-founded and helped build three influential companies in the field – Neomorphic, IDbyDNA, and Fabric Genomics.
At Neomorphic, he developed genome annotation software that enabled Affymetrix’s successful commercialization of microarray technology. He went on to launch IDbyDNA, a spinout from ARUP Laboratories, where he led the creation of the first real-time, web-based pathogen interpretation platform; the company was acquired by Illumina in 2022. Dr. Reese has also played a key role in collaborative efforts to advance genome annotation, contributing to the Berkeley Drosophila Genome Project and developing gene-finding algorithms in support of the Human Genome Project. He holds a master’s degree in Medical Informatics from the University of Heidelberg and a Ph.D. in Genetics jointly awarded by the University of Hohenheim, Germany, and the University of California, Berkeley.
His work has been instrumental in advancing genome annotation, machine learning in genomics, and the broader field of precision medicine.
Erwin Frise, PhD.
Vice President of Technology and Data ScienceÂ
Erwin Frise, Ph.D.
VP, Technology and Data Science
Dr. Frise serves as VP, Technology and Data Science. Prior to joining Fabric, Erwin was a PI at the Berkeley Drosophila Genome Project at Lawrence Berkeley National Laboratories. Working closely with the statistics department at UC Berkeley, he pioneered new methods for low dimensional statistical representations for high dimensional data, image analysis and microscope automation. Earlier he was instrumental for the annotation of the first metazoan genome (Drosophila) by contributing analysis algorithms and developing one of the first high performance compute clusters for biological genome annotation.
Dr. Frise holds a Masters degree in Molecular Biology and a Ph.D. in Genetics jointly from University of Vienna, Austria and the University of California, San Francisco.
Steven Flygare, PhD.
Vice President of Bioinformatics
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Vanisha Mistry
Vice President of Customer Success
Vanisha serves as Vice President of Customer Success focusing on ensuring that customers achieve their desired outcomes whilst using Fabric, driving customer satisfaction, retention, and growth. Before joining Fabric Genomics, Vanisha held an analyst position at Genomics England, testing the services offered by the interpretation partners and contributing to the analysis pipeline. At Fabric she supported the implementation of the Fabric software at Genomics England and led all support and training activities. She held a postdoctoral research position at the University of Cambridge in Sadaf Farooqi’s lab, performing research into early-onset obesity, alongside researchers at the well-renowned Sanger Institute. She completed her PhD under David Van Heel at Queen Mary University of London, a pioneer in discovering the genetic basis of common autoimmune diseases. Vanisha holds a Master’s Degree in Forensic Genetics, obtained at University of Central Lancashire, and a Bachelor’s in Science in Forensic Science obtained at Nottingham Trent University.
Vanisha Mistry, PhD.
Vice President of Customer Success
Vanisha Mistry
Vice President of Customer Success
Vanisha serves as Vice President of Customer Success focusing on ensuring that customers achieve their desired outcomes whilst using Fabric, driving customer satisfaction, retention, and growth. Before joining Fabric Genomics, Vanisha held an analyst position at Genomics England, testing the services offered by the interpretation partners and contributing to the analysis pipeline. At Fabric she supported the implementation of the Fabric software at Genomics England and led all support and training activities. She held a postdoctoral research position at the University of Cambridge in Sadaf Farooqi’s lab, performing research into early-onset obesity, alongside researchers at the well-renowned Sanger Institute. She completed her PhD under David Van Heel at Queen Mary University of London, a pioneer in discovering the genetic basis of common autoimmune diseases. Vanisha holds a Master’s Degree in Forensic Genetics, obtained at University of Central Lancashire, and a Bachelor’s in Science in Forensic Science obtained at Nottingham Trent University.
Sam Strom
Vice President of Clinical Operations and Clinical Genetics
Dr. Strom serves as VP, Clinical Operations and Clinical Genetics at Fabric. Prior to joining Fabric, Sam served as a laboratory director at UCLA (Department of Pathology and Laboratory Medicine) and Fulgent Genetics, and as a Principal Scientist at Illumina.
Throughout his career, he has been at the forefront of translating raw genomic data into meaningful results for patients. He has made research contributions across various clinical areas, including rare and undiagnosed genetic disorders, degenerative eye disorders, and Parkinson’s disease. With end-to-end experience in pipeline design, variant caller development, and the evaluation of AI-based candidate prioritization, Sam is strongly positioned to lead the interpretation and reporting team at Fabric.
Dr. Strom holds a PhD in Human Genetics from UCLA and is board certified in Clinical Molecular Genetics by the American Board of Medical Genetics.
Sam Strom, PhD. FACMG
Vice President of Clinical Operations and Clinical Genomics
Sam Strom
Vice President of Clinical Operations and Clinical Genetics
Dr. Strom serves as VP, Clinical Operations and Clinical Genetics at Fabric. Prior to joining Fabric, Sam served as a laboratory director at UCLA (Department of Pathology and Laboratory Medicine) and Fulgent Genetics, and as a Principal Scientist at Illumina.
Throughout his career, he has been at the forefront of translating raw genomic data into meaningful results for patients. He has made research contributions across various clinical areas, including rare and undiagnosed genetic disorders, degenerative eye disorders, and Parkinson’s disease. With end-to-end experience in pipeline design, variant caller development, and the evaluation of AI-based candidate prioritization, Sam is strongly positioned to lead the interpretation and reporting team at Fabric.
Dr. Strom holds a PhD in Human Genetics from UCLA and is board certified in Clinical Molecular Genetics by the American Board of Medical Genetics.
Russell Nofsinger, PhD.​
Vice President of Genomic Medicine
History
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