Fabric AI

Fabric Enterprise is a comprehensive platform for NGS analysis, interpretation and clinical reporting — powered by Fabric AI. Fabric AI is a proprietary set of algorithms that power interpretation and are fully integrated into Fabric Enterprise workflows.

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Fabric Enterprise

AI-driven platform converts raw genomic data into clinically meaningful and actionable insights.


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Fabric AI - Accelerate precision medicine with advanced AI technology

Fabric Enterprise is a complete end-to-end genomic data analysis solution that leverages application-specific algorithms – Fabric GEM and ACE – to perform raw data analysis and deliver rapid, comprehensive insights for whole-genome sequencing (WGS), whole-exome sequencing (WES) and target panels.

Rare disease


Rare & undiagnosed diseases



Ultra-rapid NICU & PICU cases




Re-analysis of negative cases


Hereditary Panels


Re-analysis of negative cases


AI-Driven Insights

Fabric Enterprise utilizes application-specific algorithms to support a broad set of genomic analysis use cases.

Explore each algorithm below

Fabric GEM

Fabric GEM: Learn More

For whole-genome sequencing (WGS) and whole-exome sequencing (WES)

  • Identifies causative variants and genes for rare disease diagnoses
  • Greatly reduces variant interpretation and clinical reporting times
  • Enables cost-effective re-analysis
  • Increases diagnostic throughput without resource expansion
  • Exceptional accuracy


ACE: Learn More

For panel applications

  • ACMG-compliant automated classification engine
  • Utilizes deep gene curation
  • Extensively validated across >50,000 variants
  • Currently available for hereditary cancer, newborn screening and ACMG incidental findings


For whole genome, exome, and medical exome applications

  • Speeds time to results and improves diagnostic yield
  • Ranks genes based on likelihood to cause disease, using functional impact on protein product, conservation across species, and allele frequency
  • Clinically validated with over peer-reviewed 50 publications


For whole genome, exome, and medical exome applications

  • Re-ranks genes already prioritized by VAAST using Human Phenotype Ontology (HPO) terms to further increase diagnostic yield
  • Uses a unique network propagation approach to identify additional gene candidates based on specific phenotype(s)


For whole genome, exome, as well as panel applications

  • Single variant genotype scoring that integrates sequence conservation, the type of sequence change, allele frequencies, zygosity and 
gene-specific burden
  • Facilitates variant interpretation using ACMG guidelines

Phevor is the application of mathematics to biology to get the most out of a child’s genome to identify diseases or find disease-causing gene mutations.

MARK YANDELL, Ph.D., Co-Director USTAR Center for Genetic Discovery, Assoc. Director Program in Personalized Health

Our Platform

Fabric Enterprise is a comprehensive computational genomics platform supporting high throughput panels, exomes and whole genomes for hereditary disease and oncology. Platform capabilities include:

  • Accurate alignment and variant calling
  • Up-to-date, validated variant annotation
  • Probabilistic variant ranking with advanced algorithms
  • ACMG and AMP guideline-driven variant classification and interpretation
  • Configurable SOP-based workflows
  • Customizable clinical report generation
  • Full LIMS and EMR integration capabilities

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