Interpretation of Next-Generation Sequencing Panels

Launching and Scaling NGS Testing for Diagnostics or Risk Screening

Advances in next generation sequencing (NGS) coupled with decreased costs and growing reimbursement are opening the door for broader clinical use of NGS. With the efficiencies gained leveraging technologies such as Fabric ACE and current sequencing costs, clinical labs can achieve scale and profitability with genomic panel testing. Clinical utility and reimbursement are driving high volumes, particularly for hereditary risk screening for breast and gynelogical cancers and cardiac conditions. Newborn screening and carrier screening as well as broader screening for cancers and neurological diseases are also improving clinical care. Panels are used to analyze specific mutations, sets of genes, or gene regions associated with a disease or phenotype.

Fabric ACE

As NGS testing volume in your lab increases, interpretation efficiency and turnaround times become critical. However, a significant part of the cost involves the manual and time-consuming assessment of variant pathogenicity by trained clinical geneticists. Fabric optimizes this process with ACE – an extensively validated, AI-based inference engine implementing the ACMG-AMP criteria. ACE leverages deep gene and variant annotation for highly accurate ACMG variant classification, providing a complete FASTQ-to-clinical report workflow. Fabric ACE is available for over 1,000 genes in the most-used genetic testing panels and has been validated across more than 100,000 variants in a broad range of genes, including ACMG incidental findings, inherited cancers, and newborn screening tests. Fabric ACE enables labs to scale up testing, looking comprehensively at even the rarest variants while reducing processing effort and cost.

Fabric Enterprise

Fabric Enterprise is the leading analysis software for genomic testing, providing best-in-class variant interpretation from raw sequencing data to clinical report. Fabric Genomics offers diagnostic labs the flexible tools to quickly interpret genomic data and minimize turnaround time with standard step-by-step workflows. Fabric provides comprehensive product support from FASTQ or VCF data to clinical reports, including secondary and tertiary analysis. Fabric Enterprise is modular and enables labs to offer a more extensive diagnostic menu of reimbursable tests quickly by providing tools to create custom panels, workflows, and physician-ready reports easily.

Fabric Clinical Services

Fabric Genomics possesses the genomics expertise and a deep bench of experts to help your lab quickly launch and scale NGS testing. We work with many labs that are new to NGS and help them get up and running and testing quickly. We offer a range of services to take our customers from test planning and assay selection and validation to certified, scaled testing. We work with both labs that are new to NGS and the largest testing organizations in the world.

Fabric Enterprise: A Complete Solution for Hereditary Panels, Somatic Cancer Panels, and Whole Genomes

Rapid and Accurate Testing

Comprehensive solution from FASTQ or VCF file to the clinical report
Works with any NGS sequencer and any validated assay
Customized or off-the-shelf assay and genetic test
Best practices alignment and variant calling pipelines deliver high-quality analysis 20-50x faster at a lower cost
Robust and fast annotation from >90 public and proprietary data sources
Custom clinical reporting solutions

ACMG Classification Standards

Easily adopt the ACMG standards for variant classification with Fabric ACE – AI Classification Engine
Standardize your institution’s classification methodology with a fully auditable history of scoring decisions

Flexible Clinical Reporting

Fully customize your clinical report with desired formats, content, and brand
Export clinical report content directly to Electronic Medical Record (EMR) or other systems

Full LIMS and EMR Integration

Easy integration with Laboratory Information Management Systems (LIMS) or EMR to ensure automated and consistent transfer of lab and patient information
Upload of patient and test information, as well as export of results and clinical reports

Streamlined Interpretation and Classification

The 2015 ACMG guidelines were developed to provide clinical labs with a consistent, standard method for interpreting genetic variants. Fabric Enterprise delivers automated ACMG-compliant classification powered by ACE, Fabric’s AI variant Classification Engine.

Classified Variant Database

Underlying evidence and annotations are easily accessible for rapid review by variant scientists. In addition, as laboratories classify variants, Fabric Genomics’ platform automatically stores this information and builds a comprehensive genomic knowledge base. This enables laboratories to leverage publicly available data, the lab’s historical variant classification data, and new knowledge created through the classification process. Leveraging this database, the vast majority of cases are classified automatically.

Accelerated Turnaround Times with Increased Efficiency and Consistency

Fabric Genomics’ platform allows labs to configure standard workflows for their unique testing protocols, providing scientists a step-by-step procedure for triaging and classifying variants. Flexible workflow configurations enable labs to quickly identify negative reports for batch approval, introduce multiple levels of review, and specify read or read/write access to cases at various stages of interpretation, review, or report generation.

Fabric’s dashboards and notifications enable lab directors and variant scientists to take immediate action on cases as they move through the interpretation, review, and reporting workflow. Colleagues can easily collaborate through case-level and variant-level notes.

Secure and Cloud-Based

Fabric Enterprise is a cloud-based application that scales seamlessly as your lab grows. Fabric Genomics matches or exceeds regulatory requirements, guidelines, and standards for the privacy and security of patient data.

Accessed via 128-bit SSL encryption; hosted in a secure data center with 24/7 monitoring
Cloud architecture includes redundant server and backup for all annotated variant, report, and patient data
HIPAA, ISO-27001, CAP, and CLIA compliance programs
US FDA Code of Federal Regulations 21 Part 11 compliant programs for electronic signatures