Fabric AI

Fabric Enterprise is a comprehensive platform for NGS analysis, interpretation and clinical reporting — powered by Fabric AI. Fabric AI is a proprietary set of algorithms that power interpretation and are fully integrated into Fabric Enterprise workflows.

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Fabric Enterprise

AI-driven platform converts raw genomic data into clinically meaningful and actionable insights.

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AI-Driven Insights

Fabric AI powers Fabric Enterprise workflows with AI, machine learning and statistical algorithms to accelerate interpretation and increase diagnostic yield.

VAAST

For whole genome, exome, and medical exome applications

  • Speeds time to results and improves diagnostic yield
  • Ranks genes based on likelihood to cause disease, using functional impact on protein product, conservation across species, and allele frequency
  • Clinically validated with over peer-reviewed 50 publications

Phevor

For whole genome, exome, and medical exome applications

  • Re-ranks genes already prioritized by VAAST using Human Phenotype Ontology (HPO) terms to further increase diagnostic yield
  • Uses a unique network propagation approach to identify additional gene candidates based on specific phenotype(s)

VVP

For whole genome, exome, as well as panel applications

  • Single variant genotype scoring that integrates sequence conservation, the type of sequence change, allele frequencies, zygosity and 
gene-specific burden
  • Facilitates variant interpretation using ACMG guidelines

ACE

For panel applications

  • ACMG compliant automated classification engine
  • Utilizes deep gene curation
  • Extensively validated across >50,000 variants
  • Currently available for hereditary cancer, newborn screening and ACMG incidental findings

More Information on ACE >>

Publications

Phevor is the application of mathematics to biology to get the most out of a child’s genome to identify diseases or find disease-causing gene mutations.

MARK YANDELL, Ph.D., Co-Director USTAR Center for Genetic Discovery, Assoc. Director Program in Personalized Health

Our Platform

Fabric Enterprise is a comprehensive computational genomics platform supporting high throughput panels, exomes and whole genomes for hereditary disease and oncology. Platform capabilities include:

  • Accurate alignment and variant calling
  • Up-to-date, validated variant annotation
  • Probabilistic variant ranking with advanced algorithms
  • ACMG and AMP guideline-driven variant classification and interpretation
  • Configurable SOP-based workflows
  • Customizable clinical report generation
  • Full LIMS and EMR integration capabilities

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