Fabric Enterprise is an end-to-end precision medicine platform for genomic data analysis, interpretation, and clinical reporting. The platform enables labs to easily offer a more extensive diagnostic menu of reimbursable panels, as well as support whole exome and genome tests. Fabric Genomics is a proven partner for hospital labs, commercial diagnostic labs, country genome programs, and research institutions that are implementing or scaling NGS testing.
Fully Automated Secondary Analysis for Clinical Labs
Fabric Enterprise includes an optimized, best-practices alternative to BWA-GATK that allows labs to quickly launch and process NGS data with confidence. After implementation, all aspects of secondary analysis are automated, and variants are ready for interpretation using Fabric’s advanced algorithms and efficient workflow. This seamless solution minimizes manual steps, enabling labs to reduce turnaround times and deliver clinical reports.Â
Fabric Enterprise
High-quality clinical results start with accurate secondary analysis and VCF files. With the inclusion of secondary analysis in Fabric Genomics’ solution, customers have a single seamless platform from sequencer output to clinical report, with superb scientific accuracy and speed.
Faster Secondary Analysis Compared to Industry Standard BWA-GATK
Fabric Genomics delivers a fast, accurate, and consistent secondary analysis platform using Sentieon’s algorithm, winner of the 2016 Precision FDA Truth Challenge and the Precision FDA Consistency Challenge. In the Consistency Challenge, Sentieon won for top overall performance as well as for highest reproducibility. In the Truth Challenge, Sentieon’s results were very similar to the industry-standard BWA-GATK because the mathematics are identical. However, Sentieon had a performance edge because it does not down-sample reads and handles threading more robustly than BWA-GATK. Incorporation of Sentieon enables Fabric Genomics to offer 10x faster alignment and 20-50x faster variant calling compared to the industry standard BWA-GATK.Â
Customizable Quality Control ManagementÂ
Ensuring that samples are rigorously checked for quality is a
crucial component of a robust analysis solution. Fabric Genomics’ implementation team works with your lab to ensure that the quality control workflow meets your lab’s guidelines. Default metrics can provide a starting point and can be customized to your needs. Samples within pre-specified bounds can be automatically passed if desired, and roles within the lab for the pass/fail QC process can be defined. An audit trail is automatically generated for these activities. QC metrics are visible at the per-sample level and also across samples. Additionally, QC metrics can be included in the clinical report output. Pileups can be viewed with the Integrated Genome Viewer (IGV) to validate individual variant quality during variant review.
Setup, Implementation, and Customer SupportÂ
Fabric Genomics’ Clinical and Implementation Services help customers set up and implement our software quickly. We have built our reputation on delivering the highest level of customer service and support.
Secure and Cloud-BasedÂ
Fabric Enterprise is a cloud-based application that scales seamlessly as your lab grows. Fabric Genomics matches or exceeds regulatory requirements, guidelines, and standards for the privacy and security of patient data.
